c-Src is a non-receptor tyrosine kinase and chromatin-remodeling factor that modulates gene accessibility and osteoclast function.151 Although less extensively studied in periodontitis than c-Fos and NFATc1, c-Src has emerged as a key regulator of bone resorption and inflammatory signaling.151 In osteoclasts, c-Src promotes actin ring formation and cytoskeletal organization, essential for bone resorptive activity.165 It also modulates transcriptional programs by facilitating the binding of NFATc1 and c-Fos to their target genes. This evidence concerns the gene NFATC1 and periodontitis.