TNFSF11 and periodontitis: In periodontitis models, LA reduces bone loss by downregulating chemokine signaling and suppressing MAPK pathway activation.281 Similarly, Lycii Radicis Cortex (LRC), derived from Lycium chinense Mill, decreases bacterial load, oxidative stress, and inflammation while preserving connective tissue and alveolar bone via MAPK/NF-κB modulation and RANKL/OPG regulation.282