Stattic, a small-molecule inhibitor of STAT3 dimerization and DNA binding, suppresses RANKL-induced osteoclastogenesis by downregulating NFATc1 and c-Fos expression and attenuates bone loss in an ovariectomy model.276 Stattic also inhibited STAT3 and NF-κB signaling, with minimal impact on MAPK pathways, supporting its potential role in managing inflammatory bone diseases; however, further studies in periodontitis are needed.276. The gene discussed is FOS; the disease is periodontitis.