Targeting this axis has emerged as a promising therapeutic strategy for osteolytic diseases, including periodontitis.A previous study showed that OPG−/− mice exhibit more severe alveolar bone resorption, particularly in cortical areas, compared to RANKL-overexpressing transgenic (Tg) mice, despite having higher circulating RANKL levels.264 This finding suggests that OPG deficiency exerts a more pronounced effect on bone resorption than RANKL overexpression alone. This evidence concerns the gene TNFRSF11B and periodontitis.