Gene therapy with OPG reduces alveolar bone loss in mice by blocking RANKL–RANK binding.271 OPG-based approaches have shown promise in mitigating bone resorption in inflammatory diseases, including periodontitis.272 However, similar concerns about osteonecrosis of the jaw will likely limit OPG-centered approaches for periodontitis management. This evidence concerns the gene TNFRSF11B and periodontitis.