AKT1 and periodontitis: In the mouse periodontitis model, local administration of GaELNs significantly reduces gingival inflammation and alveolar bone resorption, and decreases the expression of inflammatory mediators (TNF-α, IL-12, CXCL-12, and CXCL-5) through activation of the PHGDH/PI3K/Akt signaling pathway.