In a murine ligature-induced periodontitis model, kaempferol (10 mg/kg) significantly reduces alveolar bone loss (by ~63.8%), improve bone volume/tissue volume ratio and increased expression of OPN, EphrinB2, p-PI3K, p-Akt, and p-P38 in periodontal tissues of kaempferol-treated mice. The gene discussed is MAPK14; the disease is periodontitis.