It interacts with other components of the AP-1 complex, including Fosl1, to regulate genes essential for osteoclastogenesis.142 c-Fos is a crucial determinant in the lineage commitment of progenitor cells, directing them toward the osteoclast rather than macrophage lineage.143 Mice deficient in c-Fos display impaired osteoclast formation and an expansion of bone marrow macrophages, emphasizing its role in skeletal homeostasis and inflammatory bone disease.144. The gene discussed is FOS; the disease is bone inflammation disease.