TP53 and neoplasm: To define the influence of the cell of origin on the subtype of PDAC, a recent study used a set of GEMMs with expression of oncogenic Kras and deletion of Tp53 in either acinar or ductal cells.144 Specifically, the ductal cell–derived tumor signature is prominent in the basal-like/squamous subtype, whereas the acinar cell–derived tumor signature is pronounced in the classical subtype.