RHO and familial pancreatic carcinoma: In turn, active Rho is crucial for YAP/TAZ activation through actin remodeling and activation of the striatin-interacting phosphatase and kinase (STRIPAK) complex, which inactivates the upstream kinases of the Hippo pathway.198 Rho activation in PDAC patients is associated with poor prognosis.232 In view of the mechanisms discussed in the preceding sections linking YAP/TEAD with PDAC, there is considerable interest in repurposing statins for the chemoprevention of pancreatic cancer.