CREB1 and neoplasm: CREB has been implicated in the regulation of the expression of multiple genes involved in the control of cell proliferation, survival, migration, differentiation, metastasis, metabolism and extracellular matrix production.89,308,366,372 However, the gene networks activated downstream of CREB are tumor type-specific and remain incompletely understood.394 Here, we focus on plausible downstream targets of CREB that regulate subsequent biological processes of major interest in the context of PDAC, including NR4As, ATF3, YAP and FOXA1.