NFKB1 and cancer: These changes promote H2S to play a positive feedback regulatory role and inhibit the expression of nuclear transcription faction-κB (NF-κB), facilitating the transformation of tumour-related macrophages from cancer-promoting M2 type to cancer-suppressing M1 type, thus improving the immunosuppressive tumour microenvironment, and finally activating the body’s inherent immune response.