TACSTD2 and colorectal carcinoma: Importantly, in the liver metastatic cell lines KM12SM (spontaneous metastasis) and KM12L4 (experimental metastasis), generated by injecting the parental KM12C cell line into the spleen or cecum of mice to induce experimental and spontaneous liver metastasis, TROP2 was consistently markedly elevated compared to the parental KM12C cells (Figure S1E), which indicated TROP2's role in CRC liver metastatic capacity.42, 43