HIF1A and neoplasm: Moreover, immunohistochemical (IHC) analysis of paraffin‐embedded clinical specimens demonstrated markedly elevated activation of the TROP2/YBX1/HIF‐1α/PDK1/PFKFB3/H3K18la axis in liver metastatic lesions relative to primary tumours without metastasis, among which PDK1 and PFKFB3 represent the key glycolytic downstream of HIF‐1α (Figure 5O).