In stable YBX1‐ and HIF‐1α‐knockdown CRC cells (Figure S4I), TROP2 overexpression failed to significantly upregulate lactate production (Figure S4J) and H3K18la levels (Figure S4K), further supporting the role of YBX1/HIF‐1α in TROP2‐mediated lactate production. The gene discussed is HIF1A; the disease is colorectal carcinoma.