ChIP‐qPCR further confirmed H3K18la's enrichment at TROP2 promoter (Figure 5G), which was reduced by glycolytic inhibitor, siRNA for lactate transporter MCT4 or histone lactylation writer EP300 (Figure 5H), indicating that H3K18la might participate in sustaining TROP2 expression in CRC cells, thereby forming a positive feedback loop. Here, TACSTD2 is linked to colorectal carcinoma.