IL6 and Erythema: From a clinical perspective, the IL‐6 upregulation observed following Vistabex treatment warrants careful consideration, as IL‐6 is a pivotal cytokine in inflammatory processes, associated with edema, erythema, and increased skin rigidity [1, 2, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30].