SERPINE1 and diabetes mellitus: DNAm GrimAge, trained on 88 plasma proteins including plasminogen activator inhibitor 1 (PAI‐1) and growth differentiation factor 15 (GDF15), and smoking‐pack‐year—associated with cardiovascular and other age‐related diseases—predicts diabetes, cardiovascular disease, renal function decline, and overall morbidity burden (Lu et al. 2019).