DNAm GrimAge, trained on 88 plasma proteins including plasminogen activator inhibitor 1 (PAI‐1) and growth differentiation factor 15 (GDF15), and smoking‐pack‐year—associated with cardiovascular and other age‐related diseases—predicts diabetes, cardiovascular disease, renal function decline, and overall morbidity burden (Lu et al. 2019). This evidence concerns the gene SERPINE1 and cardiovascular disorder.