HmetBMI individuals exhibited hallmarks of metabolic dysfunction, including higher WHR, more severe VAT area and attenuation, elevated triglycerides, insulin resistance (Homeostatic Model Assessment of Insulin Resistance (HOMA-IR)), inflammation (C-reactive protein (CRP)), poorer adherence to an anti-inflammatory diet (Anti-Inflammatory Diet Index (AIDI))19 and reduced gut microbiome gene richness compared to LmetBMI (Fig. 2c and Supplementary Table 5). The gene discussed is CRP; the disease is Insulin resistance.