In multivariable models, the addition of metBMI eliminated the significant correlation of gene richness and 359 metabolic, dietary and inflammatory markers, including BMI, HOMA-IR, MetS, WHR, CRP, renal function, leptin and dietary variables (Supplementary Table 10), highlighting metBMI as a concise summary of inter-organ and inter-organismal interactions. The gene discussed is LEP; the disease is metabolic syndrome.