We then used imaging mass cytometry (IMC) to detect CD2+MHC-II+CCR2+ myeloid precursors and CD200+ (DKK3+FAP+CD45−CD31−) fibroblasts in the synovial tissues of individuals with early PsA who had just developed arthritis and individuals with psoriasis without arthritis (Fig. 5c). Here, CD2 is linked to arthritic joint disease.