This crucial evidence suggests that CXCR4 may primarily participate in core pathological responses of intrinsic intestinal cells (such as epithelial or stromal cells), including cell migration and survival, with effects relatively independent of variations in immune cell numbers across samples.In RA, we observed a markedly different pattern: the immune infiltration profile of RA synovial tissue showed high consistency across samples, lacking the significant heterogeneity observed in UC. This evidence concerns the gene CXCR4 and rheumatoid arthritis.