On the basis of the efficacy of Ag-SP tolerance in mouse EAE models of MS, the aim of the first-in-man trial of Ag-coupled cells was to assess the feasibility, safety, and tolerability of a tolerization regimen in patients with MS that used a single infusion of autologous peripheral blood mononuclear cells EDC-coupled with seven HLA-DR2b-restricted myelin peptides derived from myelin oligodendrocyte glycoprotein (MOG), myelin basic protein (MBP), and myelin proteolipid protein (PLP) (MOG1-20, MOG35-55, MBP13-32, MBP83-99, MBP111-129, MBP146-170, and PLP139-154) (5). Here, MOG is linked to myeloid sarcoma.