TDP2 and neoplasm: The ssGSEA analysis (Fig 2G–2I) showed that TDP2-high-expressing cells were enriched in important biological processes such as negative regulation of inflammatory response (Fig 2G), extracellular matrix remodeling (Fig 2H), and macrophage differentiation (Fig 2I), emphasizing the close relationship between TDP2-high expression and immunosuppression, myeloid immune response, and mesenchymalization of the tumor microenvironment.