TDP2 and Familial prostate cancer: We observed that transfection with shRNA-TDP2 significantly suppressed the proliferation of the prostate cancer cell lines compared to that of the cells in the blank control group, and transfection with pLV3-TDP2 plasmids inconspicuously promoted the proliferation of the prostate cancer cell lines (Figs 3A, 3B, S1C and S1D).