The study goes further to reveal that the markers of systemic inflammation (TNF-α, IL-6, IL-17), dyslipidemia (elevated triglycerides and low HDL), and endothelial activation (VCAM-1) were independently associated with IR, reaffirming the central role of adipose tissue–mediated inflammation and lipid toxicity in metabolic dysfunction. This evidence concerns the gene VCAM1 and metabolic syndrome.