This panoramic view generated a condensed network of 58 genes that predicted that AGEs fostered by chronic hyperglycemia suppress PI3K-AKT pathway, activate NF-kB signaling and elicit inflammatory responses which in turn reactivates Notch signaling Reactivation of Notch also suppresses PI3K-AKT signaling. The gene discussed is NFKB1; the disease is Hyperglycemia.