Moreover, ELISA revealed that the contents of the inflammatory factors IL-6, TNF-α, and IL-1β in the colon tissues and serum of the mice in the CB and But groups were significantly lower than those in Groups B and M (Figure 4I,J), suggesting that C. butyricum and butyrate not only ameliorated intestinal inflammation caused by tumor and the adverse effects of BTZ but also further improved systemic inflammation and thereby affect MM progression. The gene discussed is TNF; the disease is neoplasm.