In addition, we observed the local expansion of tumor cells in the paraspinal bone in MM mice and found that the phosphorylation of PI3K, AKT, and mTOR and the expression of BCL-2 were inhibited in the local tumor tissues of both CB and But groups (Figure S8D), just as the results presented in vitro. The gene discussed is PIK3CG; the disease is Miyoshi myopathy.