In a mouse model of Alport syndrome CKD resistant to VC, we examine the effects of a high-phosphate Western-type diet (HP) on the components of the CKD-MBD, including cardiac respiration.<h4>Methods</h4>Col4a5 -deficient mice and wild-type (WT) littermates were fed an animal protein 1.2% high-phosphate diet or a standard vegetable protein 0.6% phosphate diet. This evidence concerns the gene COL4A5 and Marchiafava-Bignami disease.