SYP and Cognitive impairment: Therefore, the increased expression of synaptophysin and PSD95 may indicate that AβOs cause a transient rise in synaptic markers due to greater neurotransmitter release into the synaptic cleft, which subsequently culminates in synaptic dysfunction and reduced expression, contributing to mild cognitive impairment in the early stages of AD (Baazaoui and Iqbal 2017).