INS and Glucose intolerance: However, both male and female βJNK3-KO mice exhibited glucose intolerance (Figure 1, D and E) and impaired insulin secretion (Figure 1F) only during oral glucose tolerance test (OGTT), with no differences when glucose was administered intraperitoneally (Figure 1, D, E, and G, and Supplemental Figure 4, C–F for female βJNK3-KO mice).