Moreover, in line with the results of chemotherapy, the expression of CXCL1/2 and CFB in macrophages was significantly increased in response to local radiation, evidenced by data from immunofluorescence (Figure 3I and Supplemental Figure 6F), Western blot (Supplemental Figure 6G), scRNA-Seq (Supplemental Figure 6H), and ELISA (Figure 3J) in mouse cancer models. This evidence concerns the gene CFB and cancer.