CCDC25 and neoplasm: Additionally, in agreement with findings in vitro, chemotherapy- or radiotherapy-treated breast tumor also upregulated the EMT markers, while silencing of CCDC25 in tumor cells or application of anti-CCDC25 neutralizing mAb decreased this effect (Figure 7, D–F, and Supplemental Figure 11, D–G), suggesting that NET-CCDC25 interaction played an indispensable role in EMT.