The results of ELISA and qRT-PCR assay revealed that tumor debris stimulation and engulfment remarkably elevated the expression of CXCL1/2 and CFB in mouse bone marrow–derived macrophages (BMDMs), whereas intact tumor cell treatment exerted less effect on CXCL1/2 or CFB production (Figure 4G and Supplemental Figure 8, E and F). This evidence concerns the gene CXCL1 and neoplasm.