After MEG3 siRNA the colony formation in ovarian cancer cell line was increased from 0.55 to 1.1 in DNC (p < 0.01), 0.5 to 0.95 in OXA (p < 0.05) and 0.3 to 0.6 in combination treatment (p < 0.05). The gene discussed is MEG3; the disease is ovarian cancer.