BCL2 and cancer: Several studies have also reported that curcumin exert its anti-cancer activity in cancer cells via interacting with a variety of cancer –associated molecular targets such as BAX, BCL-2, MMPs (MMP-9, MMP-2), cyclin D1, TP53 via modulating signaling pathways involved in cancer development (Choudhuri et al., 2005; Kunnumakkara et al., 2008).