From a biomechanical perspective, the fundamental mechanisms of these two diseases are vastly different: the pathological origin of PD is closely related to the abnormal aggregation of alpha synuclein, which directly destroys the integrity of the cytoskeleton and hinders axonal transport, leading to the obstruction of synaptic vesicle circulation and the failure of neuromuscular control. This evidence concerns the gene SNCA and Parkinson disease.