In line with these mechanisms, our findings of elevated total testosterone, LH, DHEA-S, glucose, insulin, HOMA-IR, TG, hs-CRP, and FAI, as well as decreased HDL-C and SHBG in PCOS women, support the role of hormonal imbalance in PCOS pathogenesis. The gene discussed is SHBG; the disease is polycystic ovary syndrome.