Notably, systematic evaluations of inflammatory biomarkers in PCOS (e.g., CRP, IL-6, TNF-α) show consistent elevations compared with controls (10); mechanistic overviews and cohort analyses in overweight PCOS further delineate mitochondrial dysfunction, altered adipokine signaling, and hepatic insulin resistance as central features of the metabolic disorder (11, 12). This evidence concerns the gene IL6 and polycystic ovary syndrome.