By aligning with HOMA-IR and hs-CRP independent of univariable correlates, CgA emerges as a potential integrative marker of the metabolic–inflammatory burden that characterizes many PCOS phenotypes (10–12).CgA may serve as a potential biomarker or pathophysiological mediator in PCOS-related insulin resistance and inflammation. The gene discussed is MAP3K14; the disease is polycystic ovary syndrome.