CGA and Hypoglycemia: Methodological differences likely explain the discrepant findings: our basal, fasting measurements and single-batch ELISA of stored sera probe chronic homeostasis, whereas hypoglycemia-challenge paradigms interrogate acute counter-regulation; in addition, contemporary evidence emphasizes chronic inflammatory signaling and metabolic reprogramming in PCOS (10–13), which aligns more closely with our basal CgA associations.