(70) confirmed that elevated LPS in PCOS mice can reach the ovaries and be recognized by macrophages, activating intracellular caspase-11 to initiate a cascade reaction of pyroptosis, leading to the cleavage of the pyroptosis execution protein Gasdermin D (GSDMD) into its active N-terminal fragment (GSDMD-N). The gene discussed is GSDMD; the disease is polycystic ovary syndrome.