Another study reported that LBP upregulates key enzymes, such as CYP7A1 and CYP8B1, activates FXR and SHP, and downregulates the FGFR4–β-Klotho complex, thereby reducing its inhibitory effect on CYP7A1 and enhancing bile acid synthesis in mouse models of hepatic steatosis and hypertriglyceridemia (76). This evidence concerns the gene NR1H4 and Hepatic steatosis.