NR1H4 and fatty liver disease: Another study reported that LBP upregulates key enzymes, such as CYP7A1 and CYP8B1, activates FXR and SHP, and downregulates the FGFR4–β-Klotho complex, thereby reducing its inhibitory effect on CYP7A1 and enhancing bile acid synthesis in mouse models of hepatic steatosis and hypertriglyceridemia (76).