Cross-tissue miRNA signaling that influences the PPARγ axis further underscores the need for human tissue profiling, longitudinal cohorts, and harmonized assays to quantify effect sizes and tissue specificity (130).Human tissue profiling, longitudinal cohorts, and standardized assays are required to define the effect sizes and tissue specificity of candidate miRNAs in T2DM. The gene discussed is PPARG; the disease is type 2 diabetes mellitus.