NOS3 and Hyperglycemia: One study found (58)that acute hyperglycemia upregulated Piezo1 expression in mouse kidneys, and cell experiments revealed that hyperglycemia upregulated Piezo1 expression and the expression/phosphorylation of p-CaMKII (phosphorylated Ca2+/Calmodulin-dependent protein kinase type II), Akt phosphorylation, and p-eNOS (phosphorylated eNOS), increasing NO production.