A study, using in vitro and in vivo AD models, evaluated the effect of liraglutide in SH-SY5Y human neuroblastoma cell line by investigating tau activation and Beta-site amyloid precursor protein cleaving enzyme 1 (BACE-1) expression (BACE-1 is a transmembrane aspartate protease, namely a key enzyme in beta-amyloid formation). This evidence concerns the gene MAPT and Alzheimer disease.