IFIH1 and type 1 diabetes mellitus: In peripheral blood mononuclear cells (PBMCs), E627* (rs35744605), A843H (rs3747517), and I923V (rs35667974) were associated with protection against T1D by reducing type I IFN-associated gene transcription following stimulation with IFNβ or poly(I:C), a MDA5 agonist (106, 107).