The major ‘G’ allele at rs6043409, which confers risk for T1D, was found to be associated with higher cell-surface levels of isoform 1 SIRPγ on both CD4+ and CD8+ T cells, while the minor ‘A’ allele reduced SIRPγ expression in a dose-dependent manner (83). Here, CD8A is linked to type 1 diabetes mellitus.