Convergence, AE exhibits unique bidirectional regulatory ability: it can directly act on the tumor immune microenvironment, such as enhancing the cytotoxicity of CD8+T cells and NK cells, promoting macrophage polarization towards M1 phenotype, and reducing key pro-inflammatory factors such as IL-6 and TNF - α; It can also effectively alleviate depressive symptoms by upregulating BDNF, restoring the balance of monoamine neurotransmitters, and reducing cortisol levels. This evidence concerns the gene TNF and neoplasm.