This study shows a significant difference between the tumor size of papillary carcinoma and galectin-1 staining, where all cases ≥ 4 cm were positively stained for galectin-1 with P-value = 0.002, while TROP-2 shows a significant difference in staining of follicular carcinoma with tumor size ≥4 cm (P-value, 0.03). The gene discussed is LGALS1; the disease is papillary carcinoma.