This work was funded by the 10.13039/501100001711SNSF grant number 215330 (IL-18 signaling in NAFLD/NASH: from mice to humans), the Foundation of the Swiss Diabetes Association, the Swisslife Foundation, the Vontobel stiftung, and the Novartis stiftung. This evidence concerns the gene IL18 and metabolic dysfunction-associated steatotic liver disease.