STING1 and melanoma: encapsulated cGAMP within polymersomes as nanovaccines (STING‐NP) to alleviate tumor growth in a poorly immunogenic B16F10 melanoma model, significantly stimulating IFN‐I responses in monocytes, macrophages, and melanoma cells, enhancing the subsequent tumor growth inhibition effects (Figure 6d–e).[95] This encapsulation approach exploits the ability of the nanoparticles to escape lysosomal degradation, thereby ensuring the effective delivery and activation of cGAMP, which plays a crucial role in mediating immune responses against tumor cells.