In a case-control study in Mexican subjects with microphthalmia/anophthalmia/coloboma (MAC) spectrum the FOXE3 p. Val201Met variant was shown to be present in 5 out of 104 FOXE3 alleles from MAC patients (4.8%) and in 3 out of 210 control FOXE3 alleles (1.42%). This evidence concerns the gene FOXE3 and microphthalmia.