Untreated infection enriched for cytokine and immune signaling pathways such as “response to cytokine,” “immune system process,” and “TNF signaling pathway,” consistent with the action of IL6, CCL2, CXCL10, CXCL11, CCL20, CXCR4, VCAM1, and SELE during endothelial inflammatory activation (riedrichs et al., 1998; Wyble et al., 1997; Shen et al., 1997). This evidence concerns the gene CXCR4 and infection.