Studies assessing an enzyme that is a target of oxidative stress damage (i.e., aconitase (Zischka et al., 2011; Sauer et al., 2011)) in livers from mice (aged 0.75–12 m) and rats (aged 2–4 m) and an enzymatic defense (MnSOD (Nagasaka et al., 2006; Ohhira et al., 1995; Sauer et al., 2011);) in liver biopsies from humans (aged 6–18 y), mice (aged 0.75–12 m), and rats (2–5 m old) yielded no overall differences between WD and controls (Figure 2C). The gene discussed is SOD2; the disease is Wilson disease.