IFNA1 and neoplasm: Tumor-associated neutrophils (TANs) can exhibit a dual role, adopting either an anti-tumor N1-like phenotype or a pro-tumor, immunosuppressive N2-like phenotype, often dependent on the cytokine context (e.g., IFN-γpromoting N1, versus TGF-βdriving N2) (Huang et al., 2024).