We plotted the cumulative probability of cancer at age of initial diagnosis comparing the three distinct variant groups to show a median age of onset at 48 years (range 8 – 67 years) for PTEN variant carriers, 59 years (range 11 – 99 years) for carriers of other P/LP cancer-related gene variants, and 61 years (range 3 – 103 years) for non-carriers (Fig. 2). Here, PTEN is linked to cancer.