HECTD4 and hypertensive disorder: Traits associated with SBP, DBP, PP, hypertension, and mean arterial pressure demonstrate highly significant enrichment across various smoking exposure groups with genes such as KCNK3, ULK4, BRAP, etc. Additionally, coronary artery disease and myocardial infarction exhibit significant enrichment across multiple gene sets with genes such as CYP17A1, CNNM2, ACAD10, ALDH2, NAA25, HECTD4, etc.