PRKN and Parkinson disease: When focusing on genes linked to early-onset PD, i.e., PRKN, PINK1, PARK7, the AUC of differentiating genetic PD from IPD based on AAO was greater (ROPAD dataset: 0.90 [CI: 0.87–0.93]; PD GENEration dataset: 0.89 [CI: 0.84–0.94]; MDSGene dataset: 0.95 [CI: 0.94–0.96], and GP2 dataset: 0.86 [CI: 0.79–0.93]).