MnFe2O4 NPs labeled with RGD bind to αvβ3-integrins strongly expressed in many tumors. Treatment of mice with RGD-MnFe2O4 NPs inducted the STING pathway and resulted in a reduced tumor growth (B16F10, CT26, 4T1) in particularly in combination with αPD-L1 therapy. The gene discussed is STING1; the disease is neoplasm.