SLC2A1 and neoplasm: IO-NPs were functionalized with glucuronic acid (NPs@GlcA) to target glucose transporters (GLUT) expressed on brain endothelial cells and glioblastoma. Systemic administration of NPs@GlcA resulted in transcytosis via the blood brain barrier and accumulation in C6 glioblastoma in mice. Magnetic hyperthermia led to substantial decrease of tumor growth.