The hepatocyte-secreted matrikine cysteine-rich angiogenic inducer 61 (CYR61)/cellular communication network factor 1 (CCN1) promotes monocyte recruitment and their polarization into pro-fibrotic phenotypes via an interleukin-1 receptor-associated kinase 4 (IRAK4)/spleen tyrosine kinase (SYK)/NF-κB-dependent cascade in NASH (122). This evidence concerns the gene IRAK4 and metabolic dysfunction-associated steatohepatitis.