HAVCR2 and Hepatic fibrosis: T-cell immunoglobulin and mucin-domain-containing protein 3 (TIM-3), constitutively expressed on monocytes and macrophages, negatively regulates M1 activation and the secretion of pro-inflammatory cytokines by reducing ROS production, which subsequently attenuates fibrotic responses in the MCD diet-induced liver fibrosis (63).