Furthermore, in a CCl4-induced murine model, miR-130a-3p cooperates with miR-142-5p to control macrophage polarization by targeting SOCS1 and PPAR-γ pathways, respectively, thereby promoting M2 macrophage polarization in the murine liver fibrosis model induced by CCl4 (89). This evidence concerns the gene SOCS1 and Hepatic fibrosis.