The ubiquitinated TIM3 then binds with phosphatidylinositol 3-kinase (PI3K), followed by inhibition of mammalian target of rapamycin (mTOR), which ultimately contributes to M2 macrophage polarization and aggravates NAFLD-associated fibrosis (92). The gene discussed is MTOR; the disease is metabolic dysfunction-associated steatotic liver disease.