Fibrinogen-like protein 2 (FGL2), markedly increased in the liver tissues of patients with liver cirrhosis and HCV infection, promotes mitochondrial ROS production by interacting with heat shock protein 90 (HSP90) to disrupt protein kinase B (Akt/PKB) phosphorylation as well as downstream forkhead box O1 (FOXO1) phosphorylation. Here, FGL2 is linked to cirrhosis of liver.