In murine models of MASLD, phosphorylation of PKM2 enhances glycolytic flux, promoting the polarization of macrophages toward a proinflammatory phenotype that exacerbates steatohepatitis and fibrosis, a process mediated in part by NLRP3 inflammasome activation (162). The gene discussed is NLRP3; the disease is metabolic dysfunction-associated steatotic liver disease.