For instance, Circ_1639 is upregulated in Kupffer cells of ethanol-fed mice, where it activates the NF-κB pathway and promotes proinflammatory factor production by sponging miR-122 and elevating tumor necrosis factor receptor superfamily member 13C (TNFRSF13C) expression in alcoholic liver disease (106). The gene discussed is TNFRSF13C; the disease is alcoholic liver diseases.