Injured hepatocytes can release adenosine triphosphate (ATP) into the extracellular space, which can be sensed by P2X purinoceptor 7 (P2X7) receptor and mediate KC activation via the NLRP3 inflammasome in the context of NAFLD (113). The gene discussed is NLRP3; the disease is metabolic dysfunction-associated steatotic liver disease.