IL-22 exerts anti-inflammatory effects by polarizing KCs to M2 phenotype via activation of the signal transducer and activator of transcription 3 (STAT3) pathway and suppression of extracellular-regulated kinase 1/2 (ERK1/2) and Akt pathways in CCl4-induced liver fibrosis (80). This evidence concerns the gene MAPK3 and Hepatic fibrosis.