PIK3R5 and Hepatic fibrosis: Another profibrotic lncRNA, Helf, interacts with RNA-binding protein polypyrimidine tract binding protein 1 (PTBP1) to promote its interaction with phosphoinositide-3-kinase regulatory subunit 5 (Pik3r5) mRNA, resulting in increased stability and activation of the Akt pathway, thus promoting hepatic macrophage polarization to M1 phenotype and liver fibrosis progression caused by CCl4 or BDL treatment (99).