Peroxidasin (PXDN) deficiency in hepatic stellate cells (HSCs) is implicated in the accumulation of reactive oxygen species (ROS), thereby promoting macrophage recruitment and skewing their polarization toward a proinflammatory phenotype via the NF-κB pathway in mouse models of liver fibrosis induced by CCl4 or a choline-deficient, l-amino acid-defined, high-fat diet (CDAHFD) (136). This evidence concerns the gene PXDN and Hepatic fibrosis.