Alterations in metabolic enzyme expression were observed following CD147 depletion in human pancreatic cancer cell lines, including downregulation of G6PD and PKM2, alongside upregulation of phosphoglycerate dehydrogenase (PHGDH), GLUT1, pyrroline-5-carboxylate reductase 1 (PYCR1), hexokinase domain containing 1 (HKDC1), and ornithine aminotransferase (OAT) (74). The gene discussed is PHGDH; the disease is familial pancreatic carcinoma.