STAT3 and neoplasm: Additionally, BSS/Lut remodel the immune microenvironment through (1): blocking STAT3 activation by inhibiting IL-10 secretion, downregulating CXCL2-dependent infiltration (9, 34, 35, 37); (2) suppressing TGF-β transcription by blocking nuclear factor of kappa light polypeptide gene enhancer in IκBα phosphorylation (34) (3), downregulating CXCL12 promoter activity, diminishing CAF chemotactic effects on tumor cells (40, 71).