For example, in atopic dermatitis, keratins such as Keratin 1 (KRT1) and Keratin 10 (KRT10) critically contribute to maintaining epidermal barrier integrity and participate in complex inflammatory networks through cytokine interactions, notably with IL-18, linking epidermal differentiation processes directly to inflammatory responses characteristic of AD (4, 158, 159). This evidence concerns the gene KRT10 and atopic eczema.