In lupus erythematosus, IFNs, particularly IFN-κ and IFN-α, amplify inflammatory cascades in the skin characterized by cytokines such as IL-6, IL-1β, and TNF-α, and chemokines (CXCL9, CXCL10), resulting in sustained immune cell infiltration. The gene discussed is IFNK; the disease is lupus erythematosus.