A statistically significant increase of cleaved caspase-3-positive cells and an approximately twofold increase of double-positive cells for ROR1 and caspase-3 (one-tailed significance) were observed by 22.0405.aF treatment compared to vehicle-treated tumors, indicating that, together with IFN-γ upregulation by FACS analysis, 22.0405.aF activates NK cells in vivo and induced tumor cell killing of ROR1-positive cancer cells (Figures 5F, G). Here, CASP3 is linked to neoplasm.