A previous study revealed the essential interaction of ZBP1 and RIPK1 in PANoptosis in Yersinia pseudotuberculosis infection and revealed that ZBP1 constitutively binds with RIPK1 to initiate the TRIFosome, a newly identified complex containing ZBP1, TRIF, RIPK1, FADD and caspase 8 that induces PANoptosis in Yersinia infection or LPS+TAK1 inhibition (5z7) treatment (11, 12, 22–24). The gene discussed is FADD; the disease is Yersinia infectious disease.