Another article reported that two patients with DLBCL experiencing grade 4 ICANS refractory to high dose of systemic steroids after CD19 CAR-T cells therapy, got rapid neurological recovery after treatment with intrathecal hydrocortisone (17), demonstrating the effectiveness of intrathecal hydrocortisone for severe ICANS. Here, CD19 is linked to diffuse large B-cell lymphoma.