In colorectal cancer models, lipid nanoparticle delivery of anti-PD-L1 nanobody mRNA and circRNA vectors co-encoding IL-15 and an anti-PD-L1 nanobody have produced robust antitumor responses and reshaped myeloid and T-cell infiltrates while maintaining a predominantly local pharmacologic footprint (175, 176). The gene discussed is CD274; the disease is colorectal cancer.