A Romanian boy with homozygous MYD88 E52del presented with an unusually broad infectious phenotype, including peritonitis due to P. aeruginosa, recurrent pneumonias caused by influenza A and coronavirus NL63, mucocutaneous candidiasis, multiple viral warts, cellulitis, and S. aureus abscesses, as well as pneumococcal meningitis at 4 years of age. Here, MYD88 is linked to pneumonia.