PTEN and renal cell carcinoma: Other important entities include MiT-family translocation RCCs, which harbor TFE3, TFEB, or MITF fusions; SDH-deficient RCC, which accumulates succinate causing epigenetic dysregulation and reductive carboxylation; and TSC1/2/PTEN/mTOR-altered variants that converge on dysregulated growth-factor/mTOR signaling.