Building on this, we further verified at the cellular level that P53, AKT3, SMYD4, and ATAD3A promote melanoma cell proliferation and invasion, and found that P53 forms an interaction network with AKT3, SMYD4, and ATAD3A, suggesting a crucial role of AKT3, P53, SMYD4, and ATAD3A in PMMC. Here, SMYD4 is linked to melanoma.