Comparison with the COSMIC and TCGA databases revealed overlapping genes between PMMC and melanoma, such as TP53, AHNAK2, and PMMC, as well as previously unreported mutated genes such as AKT3, SMYD4, ATAD3A, SIRPB1, XKR6, etc. In vitro experiments and co-immunoprecipitation validation revealed that P53 interacts with AKT3, SMYD4, and ATAD3A, forming a network potentially involved in the pathogenesis of PMMC. Here, SMYD4 is linked to melanoma.